Synthesis, molecular dynamics, antimicrobial activity and wound healing application of new methylidene dyes based on pyrrolinone esters

Abstract

This study presents the synthesis and characterization of novel methylidene dyes based on pyrrolinone esters with promising applications in antimicrobial therapy and wound healing. The research combines synthetic organic chemistry with molecular dynamics simulations to understand structure-activity relationships and optimize therapeutic efficacy.

Key Highlights

• Novel synthesis of methylidene dyes from pyrrolinone ester precursors
• Comprehensive molecular dynamics simulations for mechanistic insights
• Potent antimicrobial activity against pathogenic bacteria
• Enhanced wound healing properties in biological models
• Structure-activity relationship analysis for optimization

Research Impact

The development of multifunctional therapeutic agents addresses critical healthcare challenges in infection control and wound management. This work provides a foundation for developing next-generation antimicrobial and wound healing treatments.

Methodology

The research employed advanced synthetic techniques, spectroscopic characterization, molecular modeling, and biological testing to establish the therapeutic potential of the synthesized compounds.