Synthesis of New D–π–A Phenothiazine-Based Fluorescent Dyes: Aggregation Induced Emission and Antibacterial Activity

Abstract

This research presents the synthesis and characterization of novel D–π–A phenothiazine-based fluorescent dyes exhibiting unique aggregation-induced emission (AIE) properties combined with potent antibacterial activity. The compounds represent a new class of multifunctional materials with potential applications in biomedical imaging and antimicrobial therapy.

Key Innovations

• Novel D–π–A (donor-π-acceptor) molecular architecture
• Phenothiazine core as electron-rich donor moiety
• Aggregation-induced emission (AIE) characteristics
• Strong antibacterial properties against pathogenic bacteria
• Potential for theranostic applications

Scientific Significance

Aggregation-induced emission dyes have gained significant attention due to their unique photophysical properties and biomedical applications. This work contributes to the development of AIE-active compounds with dual functionality, combining optical properties with therapeutic activity.

Research Applications

The synthesized compounds show promise for applications in fluorescence imaging, bacterial detection, and antimicrobial therapy, representing a significant advancement in multifunctional fluorescent materials.